Activity of nuclear factor κB in lymphocyte populations of children with psoriasis

Alterations in intracellular signaling pathways affecting immune cell activation, proliferation and differentiation of keratinocytes psoriasis could explain the complex pathogenesis disease. NF-κB is one pathways, which involved regulation numerous pro-inflammatory genes, affects synthesis cytokines directly development psoriasis. The study was aimed to assess number cells with translocation lymphocyte populations children depending disease severity therapy. A total 130 vulgaris were examined. comparison group included 30 healthy children. conducted using imaging flow cytometry Amnis ImageStreamX system. It found that there significant differences both group. Children had a higher T helper cells, Tact, Treg, Th17 compared (p < 0.05). correlated PASI (Rmul = 0.32) BSA 0.31) scores, as well duration determination be considered an additional criterion for assessment degree reduction 24 h after administration biologics (adalimumab, etanercept, ustekinumab) have been shown. Studying offers prospect understanding pathogenetic mechanisms inflammation developing new therapeutic methods